The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding.Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales.We used quantitative imaging to track dynamic changes in endogenous labelled proteins across peripheral tissues
A putative quantifier of consciousness, integrated information, was applied to preterm infant EEG data after novel pre-processing.Integrated information had a non-random structure as a function of Accessories the time lag over which it was computed.For most lags, it increased with age in early life, but even more so in infants exposed to Family Nur
ABSTRACTHistorically, developed countries have benefited from the biodiversity and traditional knowledge of developing countries.Since the Convention on Biological Diversity (CBD) was approved, the world-view regarding access to biological resources has changed.This change marked the introduction of legal agreements regarding access to genetic reso
Summary: Droplet-based single-cell RNA-seq (scRNA-seq) data are plagued by ambient contaminations caused by nucleic acid material released by dead and dying cells.This material is mixed into the buffer and is co-encapsulated with cells, leading to a lower signal-to-noise ratio.Although there exist computational methods to remove ambient contaminati
Alpinia officinarum, which attracts attention with its antioxidant and anti-inflammatory properties, is used in traditional medicine, especially to relieve stomach and digestive system disorders.Although many studies Bikini top have revealed the various pharmacological effects of Alpinia officinarum, the effect of different ionic solvents on its bi